Buy JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2.
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ChemSpider ID: 8558143
ChEMBL Id: 561013
PubChem CID: 10382701
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SKU: N/A Category: Research Chemicals
It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as legal cannabis herbal incense blends? which in some countries are sold legally as incense labeled not for human consumption.
JWH 018 is one of these compounds, with studies showing an affinity for the cannabinoid (CB1) receptor five times greater than that of THC. Buy jwh 018 online, Cannabinoid receptors are found in the mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown. On December 15, 2008, it was reported by the German pharmaceutical company; THC-Pharm, that JWH 018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense in a number of countries around the world since 2002.
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Metabolism of JWH-018 was assessed using Wistar rats which had been administered an ethanolic extract containing JWH 018. Urine was collected for 24 hours, followed by extraction of JWH 018 metabolites using
both liquid-liquid extraction and solid-phase extraction.
GC-MS utilized to separated and identify the extracted compounds. JWH-018 and N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal. Buy jwh-018 online.
The observed mass shift indicates that it is likely that hydroxylation occurs in both the naphthalene and indole portions of the molecule.
Human metabolites were similar although most metabolism took place on the indole ring and pentyl side chain, and the hydroxylated metabolites were extensively conjugated with glucuronide.
At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence.
JWH-018 has proven to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids. On October 15, 2011, Anderson County coroner Greg Shore attributed the death of a South Carolina college basketball player to drug toxicity and organ failure caused by JWH-018.
An email dated Nov 4, 2011,?concerning the case finally released by the city of Anderson S.C on Dec 16, 2011, under the Freedom of Information Act after multiple requests by media to see the information had been denied.
Compared to THC, which is a partial agonist at CB1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. THC has shown to inhibit GABA receptor neurotransmission in the brain via several pathways.
JWH-018 may cause intense anxiety, and agitation, in rare cases (generally with non-regular JWH users). This is assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC.
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